Study M065
Study name | Woo HI 2015 |
Title | Plasma amino acid profiling in major depressive disorder treated with selective serotonin reuptake inhibitors |
Overall design | The aim of this study was to perform amino acid profiling to discover potential biomarkers in major depressive patients treated with selective serotonin reuptake inhibitors (SSRIs). Amino acid profiling using aTRAQTM kits for Amino Acid Analysis in Physiological Fluids on a liquid chromatography-tandem mass spectrometry (LC-MS/MS) system was performed on 158 specimens (plasma) at baseline and at 6 weeks after the initiation of SSRI treatment for major depressive patients and healthy controls. Therapeutic response was defined as a 50% or more reduction of HAM-D score by 6 weeks after the initiation of antidepressant treatment. Differences of baseline amino acids between depressed group (n = 68) and (control group, n = 22), and between response group (n = 48) and non-response group (n = 20) of depressed group were identified. Plasma concentrations of amino acids for the depressed group (n = 68) at baseline and at 6 weeks after the antidepressant treatment in depressive patients were also compared. |
Study Type | Type1; Type2; Type4; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV diagnosed MDD, HAMD-17 >= 15 |
Sample size | 90 |
Tissue | Peripheral; Blood; Plasma; |
Platform | MS-based; LC-MS: Agilent 1260 Infinity LC system with Agilent 6460 Triple Quadrupole MS/MS (Agilent Technologies Inc., Santa Clara, CA, USA); |
PMID | |
DOI | |
Citation | Woo HI, Chun MR, Yang JS, et al. Plasma amino acid profiling in major depressive disorder treated with selective serotonin reuptake inhibitors. CNS Neurosci Ther 2015;21(5):417-24. |
Metabolite | L-Glutamic acid; L-Methionine; L-Alanine; L-Asparagine; L-Arginine; L-Cystine; Ethanolamine; Beta-Alanine; Sarcosine; 3-Aminoisobutanoic acid; |
