Study M064
Study name | Tian JS 2015a |
Title | [Analysis on endogenous metabolites in cecal tissue of CUMS-induced depression rats after Xiaoyao San intervention by GC-MS metabolomics] |
Overall design | The aim of this study was to investigate the changes of endogenous metabolites in cecal tissue of chronic unpredictable mild stress (CUMS) -induced depression rat model interfered by Xiaoyao San via GC-MS metabolomics. CUMS rat model was used and Xiaoyao San and fluoxetine hydrochloride (fluoxetine) treatment were intervention drug. Rats were randomly divided into 4 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stress plus fluoxetine treatment at the dose of 6 mg/kg), (4) CUMS + Xiaoyaosan group (stress plus Xiaoyaosan treatment at the dose of 46.2 g/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via gastric intubation once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Gut; Cecum; |
Platform | MS-based; GC-MS: Trace GC-PolarisQ MS (Thermo Fisher Scientific Inc., Waltham, MA, USA); |
PMID | |
DOI | |
Citation | Tian JS, Zuo YM, Sun HF, et al. [Analysis on endogenous metabolites in cecal tissue of CUMS-induced depression rats after Xiaoyao San intervention by GC-MS metabolomics]. Chinese Traditional and Herbal Drugs 2015;46(13):1931-6. (Article in Chinese) |
Metabolite |
