Study M062
Study name | Shao WH 2015 |
Title | Combined metabolomics and proteomics analysis of major depression in an animal model: perturbed energy metabolism in the chronic mild stressed rat cerebellum |
Overall design | In this study, the chronic mild stress (CMS) rat model of depression was used to reveal the individual differences in stress response. Employing a gas chromatography/mass spectrometry metabolomic approach, the molecular changes associated with stress resilience in rat cerebellum were characterized by comparing anhedonic, CMS resilient and control groups. The initial experimental group contained 81 rats. Rats were divided into 2 groups: (1) control group and (2) CUMS group. The CUMS stress procedure lasted for 4 weeks. Eight samples per group were used for metabonomic analysis. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test, forced swimming test |
Sample size | 16 |
Tissue | Central; Brain; Cerebellum; |
Platform | MS-based; GC-MS: Agilent 7980 GC system with Agilent 5975 mass selective detector (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Shao WH, Chen JJ, Fan SH, et al. Combined metabolomics and proteomics analysis of major depression in an animal model: perturbed energy metabolism in the chronic mild stressed rat cerebellum. OMICS 2015;19(7):383-92.; Shao WH, Fan SH, Lei Y, et al. Metabolomic identification of molecular changes associated with stress resilience in the chronic mild stress rat model of depression. Metabolomics 2013;9:433-43. |
Metabolite | 3-Hydroxybutyric acid; L-Phenylalanine; L-Proline; Glycine; L-Glutamine; |
