Study M060
Study name | Liu ML 2015 |
Title | Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study |
Overall design | The aim of the present study was to characterize the alternations of glucose metabolites and identify potential diagnostic biomarkers for schizophrenia and major depression. Gas chromatography/mass spectrometry based targeted metabolomic method was used to quantify the levels of 13 glucose metabolites in peripheral blood mononuclear cells (PBMCs) derived from two groups (n = 55 for each group): (1) control group, (2) depressed group. The training set included 35 participants for each group, and the test set included 20 participants for each group. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | DSM-IV-TR diagnosed MDD |
Sample size | 110 |
Tissue | Peripheral; Blood; Peripheral blood mononuclear cell; |
Platform | MS-based; GC-MS: Agilent 7890A GC system with Agilent 5975 mass selective detector (Agilent Technologies Inc., USA); |
PMID | |
DOI | |
Citation | Liu ML, Zhang XT, Du XY, et al. Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study. J Transl Med 2015;13:226. |
Metabolite |
