Study M059
Study name | Liu CC 2015 |
Title | Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: a 1H NMR-based metabolomics approach |
Overall design | The current study was aimed at discovering biomarkers and biochemical pathways to facilitate the diagnosis of depression and the efficient evaluation of Xiaoyaosan using plasma metabolomics profiles based on 1H NMR. During this study, for all subjects, the decoctions of Xiaoyaosan were supplied for 8 weeks. The participants included 2 groups (n = 16 in each group): (1) control group, and (2) depressed group. 1H NMR-based metabolomics techniques and multivariate statistical methods were used to analyze the plasma metabolites of the depressed patients before and after treatment (Xiaoyaosan for 8 weeks) and to compare them with healthy controls. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Human; |
Categories of depression | Depressive disorder; Depression; Depression; |
Criteria for depression | CCMD-3 diagnosed MDD, HAMD-17 between 17 and 24 |
Sample size | 32 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker 600 MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Liu CC, Wu YF, Feng GM, et al. Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: a 1H NMR-based metabolomics approach. J Affect Disord 2015;185:156-63. |
Metabolite | Citric acid; L-Phenylalanine; |
