Study M056
Study name | Chen L 2015 |
Title | [Anti-depressive mechanism of Fufang Chaigui prescription based on neuroendocrine hormone and metabolomic correlation analysis] |
Overall design | The aim of this study was to elucidate the anti-depressive effect of Fufang Chaigui prescription (FFCGF) and its mechanism and investigate its effect on neuroendocrine hormone. Rats were included into a chronic unpredictable mild stress (CUMS) model. The changes in endogenous metabolites were analyzed by using 1H NMR metabolomics to seek the potential biomarkers. Rats were divided into 7 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stress plus venlafaxine treatment at the dose of 0.035g/kg), (4) CUMS + Xiaoyaosan group (stress plus xiaoyaosan treatment at the dose of 46g/kg), (5) CUMS + high dose of FFCGF group (stress plus FFCGF treatment at the dose of 64 g/kg), (6) CUMS + middle dose of FFCGF group (stress plus FFCGF treatment at the dose of 32 g/kg), and (7) CUMS + low dose of FFCGF group (stress plus FFCGF treatment at the dose of 16 g/kg). Eight samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 4 weeks, and drugs were administered orally once per day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 56 |
Tissue | Peripheral; Blood; Serum; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker, Germany); |
PMID | |
DOI | |
Citation | Chen L, Lliu H, Chen J, et al. Anti-depressive mechanism of Fufang Chaigui prescription based on neuroendocrine hormone and metabolomic correlation analysis. China Journal of Chinese Material Medica 2015;40(20),4080-7. (Article in Chinese) |
Metabolite |
