Study M043

Study name

Hou LJ 2014

Title

[Diagnosis of major depression in hepatitis B patients by urine metabolomics]

Overall design

The objective of this study was to explore the potential feasibility of using urine metabolomics for diagnosing the major depression (MDD) of patients with chronic hepatitis B. Metabolites in the urine of chronic hepatitis B patients with MDD (chronic hepatitis B patients with MDD group, n = 75) and chronic hepatitis B patients without MDD (chronic hepatitis B patients without MDD group, n = 64) were detected by the nuclear magnetic resonance spectroscopy and analyzed by the orthogonal partial least-squares discriminant analysis (OPLS-DA).

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression with comorbidity; Depression with comorbidity;

Criteria for depression

DSM-IV-TR diagnosed MDD, HAMD-17 > 18

Sample size

139

Tissue

Peripheral; Urine; Urine;

Platform

NMR; NMR: Bruker AVANCE III 600 spectrometer;

PMID

N/A

DOI

11.3969/j.issn.1674-8115.2014.11.018

Citation

Hou L, Xu Q, Duan S, et al. [Diagnosis of major depression in hepatitis B patients by urine metabolomics]. Journal Of Shanghai Jiao Tong University Medical Science 2014;34(11):1647-56. (Article in Chinese)

Metabolite

Citric acid;

L-Lactic acid;

L-Alanine;

Hippuric acid;

Choline;

Dimethylglycine;

Creatinine;

Taurine;

Acetic acid;

Formic acid;

Nicotinic acid;

Malonic acid;