Study M038
Study name | Chen L 2014 |
Title | [Anti-depressant effect and mechanism of supercritical CO2 extract from Compound Chaigui Fang] |
Overall design | In this study, a nuclear magnetic resonance (NMR)-based metabonomics combined with multivariate statistical analysis was performed to explore the mechanism of supercritical CO2 extract from Compound Chaigui Fang (FFCGF). Rats were divided into 7 groups (n = 10 in each group): (1) control group, (2) CUMS group, (3) CUMS + venlafaxine group (stress plus venlafaxine treatment at a dose of 35 mg/kg), (4) CUMS + Xiaoyaosan group (stress plus Xiaoyaosan treatment at a dose of 46 g/kg), (5) CUMS + high dose of FFCGF group (stress plus FFCGF treatment at a dose of 64 g/kg), (6) CUMS + middle dose of FFCGF group (stress plus FFCGF treatment at a dose of 32 g/kg), (7) CUMS + low dose of FFCGF group (stress plus FFCGF treatment at a dose of 16 g/kg). Eight samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 4 weeks, and drugs were administered during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 56 |
Tissue | Peripheral; Urine; Urine; |
Platform | NMR; NMR: Bruker AVANCE III 600 spectrometer; |
PMID | |
DOI | |
Citation | Chen L, Zheng X, Gao X, et al. [Anti-depressant effect and mechanism of supercritical CO2 extract from Compound Chaigui Fang]. China Journal of Chinese Materia Medica 2014;39(14):2744-50. (Article in Chinese) |
Metabolite |
