Study M035

Study name

Zheng P 2013b

Title

Peripheral metabolic abnormalities of lipids and amino acids implicated in increased risk of suicidal behavior in major depressive disorder

Overall design

In this study, a proton nuclear magnetic resonance (1H NMR)-based metabonomic approach was used to capture metabolic perturbations related to suicide predisposition in the context of major depressive disorder (MDD). 1H NMR spectra of plasma sampled from drug-naive depressed suicide attempters (depressed suicide attempters group; n = 21), non-attempters (depressed non-attempters group; n = 35), and healthy controls (control group; n = 35) were recorded and analyzed through a multivariate statistical approach.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression with suicide; Depression with suicide;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 > 17

Sample size

91

Tissue

Peripheral; Blood; Plasma;

Platform

NMR; NMR: Bruker AVANCE III 600 spectrometer;

PMID

N/A

DOI

10.1007/s11306-012-0474-9

Citation

Zheng P, Gao H, Qi Z, et al. Peripheral metabolic abnormalities of lipids and amino acids implicated in increased risk of suicidal behavior in major depressive disorder. Metabolomics 2013;9(3):688-96.

Metabolite

L-Valine;

Glycine;

L-Lactic acid;

L-Alanine;

L-Glutamine;

D-Glucose;

Taurine;

Pyruvic acid;

Acetic acid;

LDL;

VLDL;

Unsaturated lipid;

Cholesterol;

Acetone;