Study M031

Study name

Tian JS 2013b

Title

[1H-NMR metabonomic study on fecal of chronic unpredicted mild stress model of depression in rats]

Overall design

To obtain the potential biomarkers of chronic unpredictable mild stress (CUMS) rats, the change of endogenous metabolites in the faeces of CUMS rats was analyzed using 1H-NMR coupled with metabonomics. The change of endogenous metabolites in faeces was analyzed using 1H-NMR coupled with multivariate statistical analysis. Rats were divided into 2 groups (n = 10 in each group): (1) control group and (2) CUMS group. Six samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 4 weeks.

Study Type

Type1;

Data available

Unavailable

Organism

Rat; Sprague-Dawley rat;

Categories of depression

Animal model; Chronic mild stress model; Chronic mild stress model;

Criteria for depression

Sucrose preference test

Sample size

12

Tissue

Peripheral; Faece; Faece;

Platform

NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany);

PMID

N/A

DOI

10.7501/j.issn.0253-2670.2013.22.014

Citation

Tian J, Shi B, Feng G, et al. [1H-NMR metabonomic study on fecal of chronic unpredicted mild stress model of depression in rats]. Chinese Traditional and Herbal Drugs 2013;44(22):3170-6. (Article in Chinese)

Metabolite

L-Phenylalanine;

L-Lactic acid;

L-Glutamine;

L-Aspartic acid;

L-Tyrosine;

Uracil;