Study M030
Study name | Shi BY 2013 |
Title | A 1H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats |
Overall design | To investigate and compare the metabonomic profiles of three stress-based models of depression, the effects of acute and chronic stress on the production of systemic endogenous metabolites were investigated. Endogenous metabolites excreted in plasma were analyzed using NMR in conjunction with multivariate and statistical techniques. Rats were divided into 2 groups (n = 10 in each group): (1) control group and (2) CUMS group (chronic unpredictable mild stress). The CUMS stress procedure lasted for 4 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 20 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Bruker 600-MHz AVANCE III NMR spectrometer (Bruker Biospin, Rheinstetten, Germany); |
PMID | |
DOI | |
Citation | Shi B, Tian J, Xiang H, et al. A 1H-NMR plasma metabonomic study of acute and chronic stress models of depression in rats. Behav Brain Res 2013;241:86-91. |
Metabolite | 3-Hydroxybutyric acid; L-Valine; L-Proline; L-Glutamic acid; L-Lactic acid; |
