Study M022
Study name | Zhou YZ 2012 |
Title | Metabonomic analysis of urine from chronic unpredictable mild stress rats using gas chromatography-mass spectrometry |
Overall design | The aim of this study was to investigate the metabolic profiling of urine samples from chronic unpredictable mild stress (CUMS) rats to find potential disease biomarkers and research pathology of depression. Metabolome in urine was analyzed using gas chromatography/mass spectrometry (GC/MS) in conjunction with multivariate statistical techniques. Rats were divided into the following two groups (n = 8 in each group): (1) control group and (2) CUMS group. Six samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 3 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Polaris Q ion trap mass spectrometer (Thermo Fisher Scientific Inc., USA); |
PMID | |
DOI | |
Citation | Zhou YZ, Zheng XY, Liu XJ, et al. Metabonomic analysis of urine from chronic unpredictable mild stress rats using gas chromatography-mass spectrometry. Chromatographia 2012; 75(3-4):157-64. |
Metabolite | Palmitic acid; L-Phenylalanine; L-Valine; L-Glutamic acid; Glycine; L-Serine; L-Alanine; L-Aspartic acid; |
