Study M021

Study name

Zheng P 2012

Title

Plasma metabonomics as a novel diagnostic approach for major depressive disorder

Overall design

In this study, a NMR-based plasma metabonomic method for the diagnosis of major depressive disorder (MDD) was tested. Proton nuclear magnetic resonance (1H NMR) spectra of plasma sampled from first-episode drug-naive depressed patients (MDD group; n = 58) and healthy controls (control group; n = 42) were recorded and analyzed by orthogonal partial least-squares discriminant analysis (OPLS-DA). Moreover, the method accurately diagnosed blinded samples (n = 26) in an independent replication cohort with a sensitivity and specificity of 92.8% and 83.3%, respectively.

Study Type

Type1;

Data available

Unavailable

Organism

Human;

Categories of depression

Depressive disorder; Depression; Depression;

Criteria for depression

DSM-IV diagnosed MDD, HAMD-17 > 17

Sample size

126

Tissue

Peripheral; Blood; Plasma;

Platform

NMR; NMR: Bruker AVANCE III 600 spectrometer;

PMID

22239730

DOI

10.1021/pr2010082

Citation

Zheng P, Gao HC, Li Q, et al. Plasma metabonomics as a novel diagnostic approach for major depressive disorder. J Proteome Res 2012;11(3):1741-8.

Metabolite

myo-Inositol;

L-Valine;

L-Leucine;

Glycine;

L-Alanine;

L-Glutamine;

Creatinine;

Pyruvic acid;

LDL;

VLDL;

Unsaturated lipid;