Study M020
Study name | Zhang WY 2012 |
Title | Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats |
Overall design | In this study, a GC/MS-based metabolic profiling approach was used to investigate myocardial metabolic changes of chronic unpredictable mild stress (CUMS) rats. Principal Component Analysis (PCA) and Partial Least Squares-Discriminant Analysis (PLS-DA) were utilized to reveal differences between the model and control group. Twelve male Sprague-Dawley rats were divided into 2 groups (n = 6 in each group): (1) control group and (2) CUMS group. The CUMS stress procedure lasted for 5 weeks. |
Study Type | Type1; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 12 |
Tissue | Peripheral; Heart; Heart; |
Platform | MS-based; GC-MS: Agilent 7890 gas chromatography system with 5975C quadrupole mass spectrometer; |
PMID | |
DOI | |
Citation | Zhang WY, Liu S, Li HD, et al. Chronic unpredictable mild stress affects myocardial metabolic profiling of SD rats. J Pharm Biomed Anal 2012;70:534-8. |
Metabolite |
