Study M019
Study name | Xue SY 2012 |
Title | [Antidepressant mechanism and pharmacodynamic characteristics of venlafaxine and fluoxetine based on metabolomics] |
Overall design | The objective of this study was to evaluate and compare the antidepressant effects and mechanisms of venlafaxine and fluoxetine by metabolomic approach. Two positive drugs were employed to intervene the chronic unpredictable mild stress (CUMS) induced rat depression model. The behavioral changes of rats were observed; meanwhile, urine samples were collected and subjected to GC-MS analysis to find potential biomarkers of depression. Rats were divided into the following 4 groups (n = 8 in each group): (1) control group, (2) CUMS group, (3) CUMS + fluoxetine group (stressor plus fluoxetine at the dose of 25 mg/kg), (4) CUMS + venlafaxine group (stressor plus venlafaxine at the dose of 6 mg/kg). Six samples per group were used for metabonomic analysis. The CUMS stress procedure lasted for 3 weeks, and drugs were administered via intragastric one time each day during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 24 |
Tissue | Peripheral; Urine; Urine; |
Platform | MS-based; GC-MS: Gas chromatograph mass spectrometer (Trace PolarisQ ThermoFinnigan); |
PMID | |
DOI | |
Citation | Xue S, Zheng X, Dou C, et al. [Antidepressant mechanism and pharmacodynamic characteristics of venlafaxine and fluoxetine based on Metabolomics]. Chin Pharm J 2012;47(1):29-33. (Article in Chinese) |
Metabolite | L-Phenylalanine; L-Valine; L-Glutamic acid; Glycine; L-Serine; L-Alanine; L-Aspartic acid; Succinic acid; |
