Study M017
Study name | Liu XJ 2012a |
Title | Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy |
Overall design | The objectives of this study was to investigate the antidepressant effects of Xiaoyaosan (XYS) in a chronic unpredictable mild stress (CUMS) depression model. The changes in behaviour and plasma metabolic profiles were investigated after four-week CUMS exposure and treatment. Plasma samples were collected at 28th day, and the plasma metabolic profiling was measured using NMR, followed by multivariate analysis. Rats were randomly divided into 5 groups (n = 6 in each group): (1) control group, (2) CUMS group, (3) CUMS + middle-dose of XYS group (stressor plus XYS at a dose of 46.2 g herb/kg), (4) CUMS + fluoxetine group (stressor plus fluoxetine at a dose of 6 mg/kg), and (5) CUMS + venlafaxine group (stressor plus venlafaxine at a dose of 25 mg/kg). The CUMS stress procedure lasted for 4 weeks, and drugs were administered via gastric intubation daily during the model building period. |
Study Type | Type1; Type2; |
Data available | Unavailable |
Organism | Rat; Sprague-Dawley rat; |
Categories of depression | Animal model; Chronic mild stress model; Chronic mild stress model; |
Criteria for depression | Sucrose preference test |
Sample size | 30 |
Tissue | Peripheral; Blood; Plasma; |
Platform | NMR; NMR: Varian NMRS 600 MHz NMR spectrometer (Varian, Inc., CA, USA); |
PMID | |
DOI | |
Citation | Liu XJ, Zhou YZ, Li ZF, et al. Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy. J Pharm Pharmacol 2012;64(4):578-88. |
Metabolite | 3-Hydroxybutyric acid; L-Valine; L-Alanine; |
